解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::RNA binding proteins are critical to the maintenance of the transcriptome via controlled regulation of RNA processing and transport. Alterations of these proteins impact multiple steps of the RNA life cycle resulting in various molecular phenotypes such as aberrant RNA splicing, transport, and stability. Disruption of...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2019.03.014
更新日期:2019-04-17 00:00:00
abstract::Advancing psychiatry requires understanding brain malfunction at a microscopic scale, where neurons and synapses operate under constraints imposed by behavior, cognition, and neural architecture. Nonhuman primates are unmatched in approximating the structural and computational environment of the human brain. ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2019.02.030
更新日期:2019-04-03 00:00:00
abstract::There have been several recent studies addressing the genetic architecture of depression. This review serves to take stock of what is known now about the genetics of depression, how it has increased our knowledge and understanding of its mechanisms, and how the information and knowledge can be leveraged to improve the...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2019.03.022
更新日期:2019-04-03 00:00:00
abstract::Historically, the rat has been the preferred animal model for behavioral studies. Limitations in genome modification have, however, caused a lag in their use compared to the bevy of available transgenic mice. Here, we have developed several transgenic tools, including viral vectors and transgenic rats, for targeted ge...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.01.035
更新日期:2019-04-03 00:00:00
abstract::Light plays a pivotal role in the regulation of affective behaviors. However, the precise circuits that mediate the impact of light on depressive-like behaviors are not well understood. Here, we show that light influences depressive-like behaviors through a disynaptic circuit linking the retina and the lateral habenul...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.01.037
更新日期:2019-04-03 00:00:00
abstract::Diverse computations in the neocortex are aided by specialized GABAergic interneurons (INs), which selectively target other INs. However, much less is known about how these canonical disinhibitory circuit motifs contribute to network operations supporting spatial navigation and learning in the hippocampus. Using chron...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.01.009
更新日期:2019-03-20 00:00:00
abstract::Neurotransmitter release can be synchronous and occur within milliseconds of action potential invasion, or asynchronous and persist for tens of milliseconds. The molecular determinants of release kinetics remain poorly understood. It has been hypothesized that asynchronous release dominates when fast Synaptotagmin iso...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.01.013
更新日期:2019-03-06 00:00:00
abstract::Huntington's disease is caused by an abnormally expanded CAG repeat expansion in the HTT gene, which confers a predominant toxic gain of function in the mutant huntingtin (mHTT) protein. There are currently no disease-modifying therapies available, but approaches that target proximally in disease pathogenesis hold gre...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2019.01.039
更新日期:2019-03-06 00:00:00
abstract::The frontline anti-malarial drug artemisinin and its derivatives have also been implicated in modulating multiple mammalian cellular pathways, including the recent identification of targeting γ-aminobutyric acid type A receptor (GABAAR) signaling in the pancreas. Their molecular mechanism of action, however, remains e...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.01.001
更新日期:2019-02-20 00:00:00
abstract::Neurons can maintain stable synaptic connections across adult life. However, the signals that regulate expression of synaptic proteins in the mature brain are incompletely understood. Here, we describe a transcriptional feedback loop between the biosynthesis and repertoire of specific phospholipids and the synaptic ve...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.01.015
更新日期:2019-02-20 00:00:00
abstract::Building on Canada's strong traditions in neuroscience and ethics, neuroethics provides a backbone for the evolving Canadian Brain Research Strategy (CBRS) that, from the outset, incorporates ethically responsible discoveries in brain science into clinical, societal, educational, and commercial innovation. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.12.021
更新日期:2019-02-06 00:00:00
abstract::The motor symptoms of Parkinson's disease (PD) are thought to stem from an imbalance in the activity of striatal direct- and indirect-pathway spiny projection neurons (SPNs). Disease-induced alterations in the activity of networks controlling SPNs could contribute to this imbalance. One of these networks is anchored b...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.12.004
更新日期:2019-02-06 00:00:00
abstract::In this issue of Neuron, Royal et al. (2018) find that a mutant form of the TRESK ion channel linked to migraine undergoes alternative translation to produce an inhibitory protein that blocks TREK channels, leading to neuronal hyperexcitability and migraine in rodents. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2018.12.034
更新日期:2019-01-16 00:00:00
abstract::Currently, there are no medications that effectively treat the core symptoms of Autism Spectrum Disorder (ASD). We recently found that the bacterial species Lactobacillus (L.) reuteri reverses social deficits in maternal high-fat-diet offspring. However, whether the effect of L. reuteri on social behavior is generaliz...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.11.018
更新日期:2019-01-16 00:00:00
abstract::Binding between DIP and Dpr neuronal recognition proteins has been proposed to regulate synaptic connections between lamina and medulla neurons in the Drosophila visual system. Each lamina neuron was previously shown to express many Dprs. Here, we demonstrate, by contrast, that their synaptic partners typically expres...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.10.046
更新日期:2018-12-19 00:00:00
abstract::Nociceptin opioid peptide receptor agonists interact with mu-opioid receptor agonists for pain relief. A new study by Ding et al. (2018) examines a bifunctional nociceptin- and mu-opioid receptor agonist, AT-121, that provides analgesia without physiological side effects or abuse liability, offering a promising new ho...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2018.11.045
更新日期:2018-12-19 00:00:00
abstract::In this issue of Neuron, Ambrozkiewicz et al. (2018) define a new molecular circuit controlling neuronal polarization and migration through the transcription factor SOX9 to coordinate the production of regulators of both protein synthesis and degradation. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2018.11.022
更新日期:2018-12-05 00:00:00
abstract::The establishment of axon-dendrite polarity is fundamental for radial migration of neurons during cortex development of mammals. We demonstrate that the E3 ubiquitin ligases WW-Containing Proteins 1 and 2 (Wwp1 and Wwp2) are indispensable for proper polarization of developing neurons. We show that knockout of Wwp1 and...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.10.008
更新日期:2018-12-05 00:00:00
abstract::Neuromodulators regulate circuits throughout the nervous system, and revealing the cell types and stimulus conditions controlling their release is vital to understanding their function. The effects of the neuromodulator nitric oxide (NO) have been studied in many circuits, including in the vertebrate retina, where it ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.09.047
更新日期:2018-12-05 00:00:00
abstract::Synaptic transmission is bioenergetically demanding, and the diverse processes underlying synaptic plasticity elevate these demands. Therefore, mitochondrial functions, including ATP synthesis and Ca2+ handling, are likely essential for plasticity. Although axonal mitochondria have been extensively analyzed, LTP is pr...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.09.025
更新日期:2018-11-21 00:00:00
abstract::Theta oscillations reflect rhythmic inputs that continuously converge to the hippocampus during exploratory and memory-guided behavior. The theta-nested operations that organize hippocampal spiking could either occur regularly from one cycle to the next or be tuned on a cycle-by-cycle basis. To resolve this, we identi...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.09.031
更新日期:2018-11-21 00:00:00
abstract::In the hippocampus, gamma power modulation by the theta rhythm is interpreted as the signature of temporally coordinated inputs that reflect ongoing processing. In this issue of Neuron, Lopes-Dos-Santos et al. (2018) develop a new methodology demonstrating that theta cycles can be viewed as individual computational un...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2018.11.008
更新日期:2018-11-21 00:00:00
abstract::The eye often leads the way in the development of novel strategies for treating neurodegenerative disorders. Here, we highlight an exciting new study examining the potential for reactivating endogenous repair mechanisms and enabling the mammalian retina to repair itself. ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2018.10.035
更新日期:2018-11-07 00:00:00
abstract::Gene transcription is the process by which the genetic codes of organisms are read and interpreted as a set of instructions for cells to divide, differentiate, migrate, and mature. As cells function in their respective niches, transcription further allows mature cells to interact dynamically with their external enviro...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2018.10.013
更新日期:2018-10-24 00:00:00
abstract::Cognitive maps are encoded in the hippocampal formation and related regions and range from the spatial to the purely conceptual. Neural mechanisms that encode information into relational structures, up to an arbitrary level of abstraction, may explain such a broad range of representation. Research now indicates that s...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2018.10.006
更新日期:2018-10-24 00:00:00
abstract::The study of interneuron diversity in the spinal cord is complex and needs new models that can accelerate discovery. In this issue, Hoang et al. (2018) use ESC-derived neurons to create simplified microcircuits to study spinal interneuron diversification, connectivity, and function. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2018.09.034
更新日期:2018-10-10 00:00:00
abstract::Many animals guide their movements using optic flow, the displacement of stationary objects across the retina caused by self-motion. How do animals selectively synthesize a global motion pattern from its local motion components? To what extent does this feature selectivity rely on circuit mechanisms versus dendritic p...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.08.022
更新日期:2018-10-10 00:00:00
abstract::Non-human primate neuroimaging is a rapidly growing area of research that promises to transform and scale translational and cross-species comparative neuroscience. Unfortunately, the technological and methodological advances of the past two decades have outpaced the accrual of data, which is particularly challenging g...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.08.039
更新日期:2018-10-10 00:00:00
abstract::Conditioned appetitive and aversive responses (CRs) are thought to result from the activation of specific subsets of valence-coding basolateral amygdala (BLA) neurons. Under this model, the responses of BLA cells to conditioned stimuli (CSs) and the activity that drives CRs are closely related. We tested the strength ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.07.036
更新日期:2018-09-19 00:00:00
abstract::Memory encoding and retrieval require directional exchange of information between different areas in the medial temporal lobe. In this issue of Neuron, Koster et al. (2018) use high-resolution fMRI combined with state-of-the-art data analysis methods to trace the information flow in memory circuits in hippocampus and ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2018.09.004
更新日期:2018-09-19 00:00:00
abstract::Neuromodulators are important regulators of synaptic transmission throughout the brain. At the presynaptic terminal, neuromodulation of calcium channels (CaVs) can affect transmission not only by changing neurotransmitter release probability, but also by shaping short-term plasticity (STP). Indeed, changes in STP are ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.07.030
更新日期:2018-09-05 00:00:00
abstract::Sensory input reaching the brain from bilateral and offset channels is nonetheless perceived as unified. This unity could be explained by simultaneous projections to both hemispheres, or inter-hemispheric information transfer between sensory cortical maps. Odor input, however, is not topographically organized, nor doe...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.07.012
更新日期:2018-08-22 00:00:00
abstract::Classic studies of spatial attention assumed that its neural and behavioral effects were continuous over time. Recent behavioral studies have instead revealed that spatial attention leads to alternating periods of heightened or diminished perceptual sensitivity. Yet, the neural basis of these rhythmic fluctuations has...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.07.038
更新日期:2018-08-22 00:00:00
abstract::The pathways that convert neural stem cells (NSCs) into functional neurons in the adult hippocampus are tightly regulated. In this issue of Neuron, Yeh et al. (2018) demonstrate that the activity of dentate mossy cells determines the balance between quiescence and activation of NSCs. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2018.07.044
更新日期:2018-08-08 00:00:00
abstract::Epitranscriptomic modification of mRNA affects its metabolism and has recently been shown to regulate brain development. Two studies in this issue of Neuron, Koranda et al. (2018) and Engel et al. (2018), uncover dynamic and critical roles of m6A/m RNA modifications in the adult mammalian brain in regulating physiolog...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2018.07.019
更新日期:2018-07-25 00:00:00
abstract::The neonatal mammal faces an array of sensory stimuli when diverse neuronal types have yet to form sensory maps. How these inputs interact with intrinsic neuronal activity to facilitate circuit assembly is not well understood. By using longitudinal calcium imaging in unanesthetized mouse pups, we show that layer I (LI...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.06.002
更新日期:2018-07-11 00:00:00
abstract::Somatic mutation of the MTOR gene is a genetic etiology of focal malformations of cortical development. In this issue of Neuron, Park et al. (2018) identify defective autophagy-dependent ciliogenesis/Wnt signaling as an underlying mechanism affecting neuronal migration and cortical lamination. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2018.06.042
更新日期:2018-07-11 00:00:00
abstract::Primary familial brain calcification (PFBC) is a genetically heterogeneous disorder characterized by bilateral calcifications in the basal ganglia and other brain regions. The genetic basis of this disorder remains unknown in a significant portion of familial cases. Here, we reported a recessive causal gene, MYORG, fo...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.05.037
更新日期:2018-06-27 00:00:00
abstract::Acetylcholine release in the prefrontal cortex (PFC), acting through muscarinic receptors, has an essential role in regulating flexible behavior and working memory (WM). General muscarinic receptor blockade disrupts PFC WM representations, while selective stimulation of muscarinic receptor subtypes is of great interes...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.05.027
更新日期:2018-06-27 00:00:00
abstract::Does our understanding of the human brain remain incomplete without a proper understanding of how the brain processes music? Here, the author makes a passionate plea for the use of music in the investigation of human emotion and its brain correlates, arguing that music can change activity in all brain structures assoc...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2018.04.029
更新日期:2018-06-27 00:00:00